منابع مشابه
Somatic Mosaicism in the Human Genome
Somatic mosaicism refers to the occurrence of two genetically distinct populations of cells within an individual, derived from a postzygotic mutation. In contrast to inherited mutations, somatic mosaic mutations may affect only a portion of the body and are not transmitted to progeny. These mutations affect varying genomic sizes ranging from single nucleotides to entire chromosomes and have bee...
متن کاملThe Human Genome Puzzle – the Role of Copy Number Variation in Somatic Mosaicism
The discovery of copy number variations (CNV) in the human genome opened new perspectives in the study of the genetic causes of inherited disorders and the etiology of common diseases. Differently patterned instances of somatic mosaicism in CNV regions have been shown to be present in monozygotic twins and throughout different tissues within an individual. A single-cell-level investigation of C...
متن کاملSomatic Mosaicism and Disease
The large number of cell divisions required to make a human body inevitably leads to the accumulation of somatic mutations. Such mutations cause individuals to be somatic mosaics. Recent advances in genomic technology now allow measurement of somatic diversity. Initial studies confirmed the expected high levels of somatic mutations within individuals. Going forward, the big questions concern th...
متن کاملNew Insights Into Human Physiology Involved in Somatic Mosaicism
Induced pluripotent stem (iPS) cell technology involves the generation of pluripotent stem cells from adult somatic cells by the exogenous expression of specific reprogramming factors (see Box). This technology opened the door for us to access a robust platform demonstrating in vitro cellular reprogramming from certain somatic cells to pluripotent status. Recently, Cahan and Daley conducted a b...
متن کاملSomatic Mosaicism in Blaschkolinear Inflammatory Disorders
Linear lichen planus (LP) is a rare dermatologic disease in which lichenoid lesions conform to a blaschkolinear distribution, most commonly on the extremities. Linear discoid lupus erythematosus (DLE) is a cutaneous manifestation of lupus that also conforms to Blaschko’s lines. Blaschkolinear disorders have been shown to result from somatic mosaicism, most recently in nevus sebaceus, epidermal ...
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ژورنال
عنوان ژورنال: Genes
سال: 2014
ISSN: 2073-4425
DOI: 10.3390/genes5041064